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MeLiS Mécanismes en sciences intégratives du vivant

Energy metabolism shapes Drosophilia long-term memory

Invité par Jean-Louis BESSEREAU.

Résumé

Understanding the links between neuronal plasticity which underlies memory and energy metabolism is a major goal of brain studies. The brain is a main energy consumer and the central regulator of energy homeostasis, and it prioritizes its own supply over peripheral organs. However we have shown in Drosophila that the brain is also able to regulate its own activity under energy shortage to favor survival. I will describe how our integrated strategy to study at the molecular, circuit and behavioral levels how the brain energy status is transmitted to the drosophila olfactory memory center, and how this information is used to regulate long-term memory formation. Finally, I will present recent data linking sexual activity with memory capacity.