Welcome to MeLiS

Mechanisms in Integrated Life Sciences

Université Claude Bernard Lyon 1 – CNRS UMR 5284 – INSERM U1314

MeLiS teams are interested in the molecular mechanisms operating in a variety of cellular compartments, from cilia, membranes, axons, to synapses and circuits, with a focus on neuronal and muscular cells.

We investigate a range of biological processes and their alterations in human diseases affecting developing, adult and aging organisms.

We use a diversified approach taking advantage of a large panel of models, including: drosophila, C. elegans, zebrafish, chicken, mouse, and human. Our studies combine genetics, large-scale molecular analyses, in vivo manipulations, behavioral assays, with strong emphasis on microscopy techniques (super-resolution microscopy, expansion microscopy, in vivo 2-photon, light sheet microscopy, electron microscopy) and image quantification (segmentation, animal tracking, time-series).